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Atomic Structure01:33

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Atomic Structure

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The Greek philosopher Democritus proposed that everything on Earth is made up of tiny particles called atomos, Greek for "indivisible," from which the modern term "atom" is derived. In the 19th century, John Dalton proposed the atomic theory that is still largely correct today. He put forth five postulates to explain how atoms made up the world around us. (1) All matter is composed of infinitely small particles or atoms. (2) All atoms of a given element are identical to one...
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Seed structures are composed of a protective seed coat surrounding a plant embryo, and a food store for the developing embryo. The embryo contains the precursor tissues for leaves, stem, and roots. The endosperm and cotyledons—seed leaves—act as the food reserves for the growing embryo.
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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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An atom comprises protons and neutrons, which are contained inside the dense, central core called the nucleus, with electrons present around the nucleus. Taking into account the wave–particle duality of electrons and the uncertainty in position around the nucleus, quantum mechanics provides a more accurate model for the atomic structure. It describes atomic orbitals as the regions around the nucleus where electrons of discrete energy exist, characterized by four quantum...
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直接从种子:一个原子分辨率蛋白质结构由 ab initio MicroED.

Purna Chandra Rao Vasireddy1, Timothy Low-Beer1, Katherine A Spoth1,2

  • 1Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA.

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概括

研究人员使用微晶电子衍射 (MicroED) 实现了原子分辨率蛋白质结构. 这种方法应用于克兰宾蛋白,成功地解决了最初的结构,为高分辨率电子晶体学提供了新的基准.

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科学领域:

  • 结构生物学 结构生物学
  • 生物物理学的生物物理.
  • 晶体学 晶体学是指结晶学.

背景情况:

  • 蛋白质结构的确定对于理解生物功能至关重要.
  • 微晶电子衍射 (MicroED) 为小型或敏感晶体提供了对X射线晶体学的有希望的替代方案.
  • 实现高分辨率和解决结构的挑战仍然存在,从MicroED开始.

研究的目的:

  • 使用MicroED确定种子蛋白crambin的原子分辨率结构.
  • 为了建立一个基准 ab initio 结构解决方案与MicroED.
  • 为了证明序列合并和异质性校正对MicroED数据的有效性.

主要方法:

  • 从乙醇净化滴中自发形成蛋白质纳米晶体.
  • 在58个纳米晶体上使用微晶电子衍射 (MicroED) 收集数据.
  • 衍射数据的连续合并和异形态意识的截断.
  • Ab initio结构溶液使用五个残留的螺旋碎片进行分阶段.

主要成果:

  • 一个原子分辨率 (0.85 Å) 微ED结构的crambin被解决了 ab initio.
  • 实现了自动化模型构建和单个原子的分辨率.
  • 这项研究表明,在没有专用设备的情况下,成功地实现了微型电磁波电流下分辨率.

结论:

  • 很容易获得适合MicroED的蛋白质纳米晶体.
  • 连续合并与异质性校正相结合,可使初始的MicroED结构解决方案.
  • 这项工作为标准仪器上的高分辨率MicroED提供了一个基准.