银纳米颗粒的微生物合成,使用来自巴西无刺蜂的细菌超水体,具有抗微生物活性
Ana Carolina Costa Santos1, Joberth Lee Corrêa2, Rafaela Cavalcante Cerqueira2
1Laboratory of Genetics, Institute of Biotechnology, Federal University of Uberlândia, Acre Street, 2E Building, Room 226, Uberlândia, MG, Brazil. ana.carolina@ufu.br.
Scientific reports
|February 14, 2026
概括
使用蜜蜂幼虫食物细菌的银纳米颗粒 (AgNPs) 的绿色合成提供了一种新的抗菌战略. 这些AgNP有效地对抗抗生素耐药细菌,具有低毒性,提供可持续的解决方案.
科学领域:
- 纳米技术 纳米技术
- 微生物学 微生物学
- 材料科学 材料科学 材料科学
背景情况:
- 抗生素耐药性是全球主要的健康威胁,需要新型抗菌剂.
- 银纳米粒子 (AgNPs) 由于其抗菌性质,显示出有希望的替代品.
- 探索AgNP合成的可持续和新来源至关重要.
研究的目的:
- 为了研究AgNPs的绿色合成,使用来自巴西无刺蜂幼虫食物的细菌超级生物.
- 描述合成的AgNP并评估它们的抗菌活性.
- 评估这些AgNP的潜在生物医学和环境应用.
主要方法:
- 通过传统方法和微波辅助方法使用细菌上游生物 (Providencia rettgeri,Proteus mirabilis) 来合成AgNP的绿色合成.
- 使用UV-Vis光谱,DLS,SEM,EDX和TEM进行AgNP的表征.
- 对抗多抗药性大肠杆菌和金黄色杆菌进行抗菌活性测试.
- 用Drosophila melanogaster和人类神经元培养物纳入酸盐膜和毒性测试.
主要成果:
- 成功合成了大小从8.5-25.2nm的球形AgNP.
- 微波辅助合成导致了更快的形成和更好的同质性.
- AgNP 显示出对抗耐药性大肠杆菌和黄金色杆菌的显著抗菌活性.
- 在酸盐膜中,AgNPs保留了有效性,在生物模型中显示出低毒性.
结论:
- 从独特的微生物来源生物合成的AgNP提供了一种可持续的抗微生物方法.
- 微波辅助处理提高了AgNP合成效率.
- 这些AgNP具有生物医学和环境应用的潜力,因为它们的有效性和低毒性.
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