杏仁消费对认知表现和脑血管功能的长期影响:一种随机交叉试验,针对糖尿病前期超重/肥胖成年人进行
Micah S Adams1, Ronald P Mensink1, Jogchum Plat2
1Department of Nutrition and Movement Sciences, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, MD, the Netherlands.
European journal of clinical nutrition
|February 14, 2026
概括
在糖尿病前期的成年人中,每天吃杏仁并没有改善认知功能或大脑血流. 这项长期研究表明,杏仁在这个有风险的人群中对大脑健康没有好处.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 以前对健康人群的研究表明,杏仁干预没有对认知有益.
- 糖尿病前期患者有认知能力下降的风险,需要长期研究.
- 大脑血管功能可能是杏仁相关认知变化的关键因素.
研究的目的:
- 研究日常杏仁消费对糖尿病前期超重/肥胖成年人认知表现的长期影响.
- 评估杏仁摄入量对大脑血流 (CBF) 的影响,作为大脑血管功能的标志物.
- 为了确定杏仁是否可以减轻面临风险的人群的认知衰退.
主要方法:
- 一个随机的,单盲的,受控的交叉试验与43名参与者进行.
- 参与者每天摄入50克杏仁,持续5个月,随后进行2个月的洗和5个月的控制期.
- 在每个周期前后测量认知功能 (使用CANTAB) 和CBF (使用MRI pCASL).
主要成果:
- 34名参与者完成了这项研究,平均年龄为66岁,平均BMI为28.3kg/m2.
- 与杏仁消费一起,没有观察到心理运动速度,执行功能或记忆力的显著改善.
- 与对照期相比,杏仁摄入量没有显著影响全脑或区域大脑血流.
结论:
- 长期的杏仁消费 (50g/天) 并没有提高糖尿病前期超重/肥胖个体的认知表现.
- 杏仁没有在这个研究群体中对大脑血管功能产生显著影响.
- 这些发现与先前对健康人群的研究一致,表明杏仁在这个特定群体中的认知益处有限.
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