一个休息任务fMRI研究的空间工作记忆在艾滋病毒感染的个人跨越认知状态
Junzhuo Chen1, Zhongtian Guan2, Fan Xu1
1Department of Radiology, Beijing Youan Hospital, Capital Medical University, No. 8, Xitoutiao, You'anmenwai, Fengtai District, Beijing, 100069, China.
BMC medical imaging
|February 14, 2026
概括
与艾滋病毒相关的神经认知障碍 (HAND) 的工作记忆缺陷与大脑网络活动的改变有关. 休息到任务功能连接重新配置的变化显示出作为HAND诊断和风险分层的标记物的希望.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 传染性疾病 传染性疾病
背景情况:
- 与艾滋病毒相关的神经认知障碍 (HAND) 是常见的,工作记忆障碍是关键特征.
- 联合抗逆转录病毒疗法 (cART) 已经减少了严重的HAND,但轻度形式仍然存在.
- 识别用于早期HAND诊断的成像标志物对于有针对性的干预至关重要.
研究的目的:
- 研究与艾滋病毒感染个体的工作记忆相关的功能性大脑特征.
- 使用fMRI区分认知状态 (认知完整性与无症状神经认知障碍).
- 为了确定早期HAND诊断和风险分层的潜在成像生物标志物.
主要方法:
- 招募了59名艾滋病毒感染者 (30CI,29ANI) 和37名健康对照 (HC).
- 使用空间工作记忆任务获得休息状态和基于任务的fMRI.
- 通过使用基于网络的统计数据,分析了大脑激活,功能连接 (FC) 和从休息到任务的FC重新配置效率.
主要成果:
- 无症状神经认知障碍 (ANI) 显示工作记忆性能较差,神经认知得分低于认知完整性 (CI).
- 与CI相比,ANI表现出大脑激活模式的改变,包括额头/部活动的减少和小脑活动的增加.
- 两组艾滋病毒患者在休息时和任务期间的全脑FC增加,而不是HC;改变了休息到任务的FC重构,与免疫和认知措施相关.
结论:
- 病毒抑制的艾滋病毒的认知障碍涉及工作记忆网络参与的改变,在ANI中皮质大脑小脑参与度增加.
- 静态全脑FC显示认知组之间的分离有限.
- 剩余到任务的FC重新配置效率可以作为HAND表型和风险分层的有价值的候选标记.
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