相关实验视频

Updated: Feb 16, 2026

Detection of Histone Modifications in Plant Leaves
07:08

Detection of Histone Modifications in Plant Leaves

Published on: September 23, 2011

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通过利用DNA语言模型,预测疾病特异性基因组修饰和非编码变异的功能影响

Xiaoyu Wang1,2, Tong Pan1,2, Sihan Chen1,2

  • 1Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia.

Genome biology
|February 14, 2026
PubMed
概括

我们开发了一种深度学习框架,用于预测阿尔茨海默病 (AD) 中的组织蛋白修饰,识别疾病特异性的表观遗传特征. 这种方法准确地预测了修改,并优先考虑了与AD相关的遗传变异,以更好地了解疾病.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.深度学习是一种深度学习.基因组胺基因的修改语言模型 语言模型

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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila06:41

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Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Histone Modification02:32

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Histone Variants at the Centromere

Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
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lncRNA - Long Non-coding RNAs02:39

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In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
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