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Engineering and Evolution of Synthetic Adeno-Associated Virus AAV Gene Therapy Vectors via DNA Family Shuffling
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通过在体内编程的Treg扩张来服AAV基因治疗的免疫反应

Lavesh Gwalani1, Mincheol Park1, Alexandra B Ysasi1

  • 1Sanofi, Genomic Medicine Unit, Waltham, MA.

Molecular therapy : the journal of the American Society of Gene Therapy
|February 15, 2026
PubMed
概括

修改后的INTERLEUKIN-2 (IL-2) THOR-834扩展调节性T细胞 (Tregs),以提高腺相关病毒 (AAV) 基因治疗的疗效. 这种新的方法抑制了免疫反应,增强了转基因表达的持久性.

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