计算机建模与3D生物打印相遇:心血管疾病建模中的新兴协同作用
Tanmay Mukherjee1, Mehdi Salar Amoli2,3, Sarah Rezapourdamanab2
1Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA.
Advanced healthcare materials
|February 15, 2026
概括
先进的3D生物打印和计算建模可以创建现实的心血管 (CV) 结构. 这种整合改善了疾病建模和针对心血管疾病 (CVD) 的患者特定治疗方法.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 计算生物学 计算生物学
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 现有的体外模型很难准确地复制人类心血管生理学.
- 需要先进的诊断,治疗和疾病建模策略.
研究的目的:
- 审查最近应用到3D生物打印心血管结构的计算建模方面的进展.
- 为强调将计算建模与3D生物打印集成为CV应用程序的好处.
- 探索创建临床可翻译,针对患者的心血管平台的潜力.
主要方法:
- 关于用于心血管组织工程的3D生物打印技术的当前文献的综述.
- 分析计算建模方法,包括计算流体动力学和机器学习.
- 检查集成3D生物打印和计算建模的混合平台.
主要成果:
- 3D生物打印使生物模拟心血管结构的创建成为可能,其结构和功能复制得到了改进.
- 计算建模为血液动力学,重塑和治疗反应提供了预测性见解.
- 集成的计算和生物打印平台提高了复杂的CV条件的精度和实用性.
结论:
- 计算建模和3D生物打印之间的协同作用提供了一个强大的方法来克服当前心血管研究的局限性.
- 这些综合技术有望更准确地建模复杂的心血管疾病.
- 这一途径导致了临床翻译的患者特异性心血管平台的开发.
相关概念视频
Psychoneuroimmunology: Cardiovascular Disease
588
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
588
Emerging Adulthood
761
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
761
Stereotype Content Model
15.5K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
15.5K
Molecular Models
44.0K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
44.0K
Overview of the Cardiovascular System
12.3K
The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
12.3K
Introduction Cardiac Emergencies
383
Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
383


