口服亚酸盐补充剂对老年人线粒体呼吸和身体功能的益处
Daniel E Forman1, Subashan Perera2, Sruti Shiva3
1Department of Medicine, University of Pittsburgh (Divisions of Geriatrics and Cardiology), and Geriatrics, Research, Education and Clinical Center (GRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA.
概括
口服酸盐补充剂没有改善老年人的肌肉功能. 虽然血小板呼吸有所改善,但是骨肌肉反应表明,与年龄相关的差异在于身体如何处理酸盐.
科学领域:
- 老年学是指老年学的学科.
- 线粒体生物学 线粒体生物学
- 营养科学 营养科学
背景情况:
- 与年龄相关的线粒体功能下降会增加疾病风险.
- 口服酸盐/酸盐补充剂对年轻人有好处,但未在老年人中进行研究.
研究的目的:
- 为了研究口服酸盐对老年人 (≥70岁) 肌肉线粒体呼吸的影响.
- 评估这一人口群体对心肺健康和身体功能的影响.
主要方法:
- 一个为期12周的随机,双盲,安慰剂对照试验,涉及64名久坐不动的老年人.
- 主要结局:骨肌肉线粒体呼吸的变化 (CI&II MaxOXPHOS).
- 二次结果:血小板生物能学,运动能力和身体功能.
主要成果:
- 没有观察到骨肌线粒体呼吸,运动能力或身体功能的显著改善.
- 血小板线粒体呼吸在急性酸盐剂量后显著改善.
- 酸盐水平在血中显著增加,但在骨肌肉中剂量后的增加很小.
结论:
- 组织特异性药理动力学和药理动力学影响老年人中酸盐补充剂的疗效.
- 骨肌与血小板线粒体的不同反应表明药物递送,新陈代谢或反应能力的年龄相关变化.
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