相关实验视频

Updated: Feb 16, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

简化骨间接接收的生物启发工程:神经生物打印的节电支架用于神经血管化骨再生

Yingze Su¹, Haomin Wang², Weixi Liu¹

¹Department of Orthopaedics, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|February 15, 2026

概括

在压电支架内工程造的背脊根结节神经元 (DRG) 创建了一个独立的"传感器效应器"系统. 这在超声波刺激时增强了与素基因相关的 (CGRP) 的释放,促进了骨再生.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
神经科学是一个神经科学.

背景情况:

骨整体受体系统,涉及背部根结节 (DRG) 神经元,对于骨稳定和再生至关重要,但在组织工程中被忽视.
DRG神经元作为枢纽,分泌素基因相关 (CGRP),直接促进骨的修复.
目前的策略缺乏一个动态的,自主的功能系统,无法利用完整的反射弧.

研究的目的:

通过将DRG神经元与压电支架集成,为骨组织工程设计一个精简的整体受体单元.
开发一个生物灵感平台与一个独立的平台.
传感器 - 效应器传感器 - 效应器
自主骨再生的电路.
研究超声波 (US) 刺激作为DRG神经元介导骨修复的触发因素.

主要方法:

DRG神经元的神经生物打印在压电式多样乳酸 (PLLA) 支架内.
利用压电支架的机电联接,在美国刺激时触发DRG神经元反应.
骨质生成和血管生成的体外评估,以及在老鼠大腿缺陷模型中的体内评估.

主要成果:

该工程单位展示了机电电合,触发Ca2+流入,并在美国感应时增强DRG神经元中的CGRP分泌和表达.
在体外研究表明促进了骨质生成和血管生成.
在体内实验中,在老鼠模型中发现了加速的神经血管化骨再生.

结论:

一个新的生物灵感平台,具有集成的集成平台.
传感器 - 效应器传感器 - 效应器
成功建立了用于骨再生的循环.
这种工程系统利用DRG神经元活动和压电来增强骨修复.
这项研究提出了自主和动态骨组织工程的新策略.

关键词:

通过3D打印打印3D打印.骨再生骨再生卡尔西托宁基因相关的.压电生物材料是一种生物材料.感觉神经是感觉神经.

更多相关视频

3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue

3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue

Published on: July 16, 2021

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Published on: May 19, 2022

相关概念视频

What is the Skeletal System?

What is the Skeletal System?

Streamlines, Streaklines, and Pathlines

Streamlines, Streaklines, and Pathlines

A streamline represents the trajectory that is always tangent to the fluid's velocity vector at any given point. The velocity of a fluid particle is always directed along the streamline, ensuring the particle continuously follows the streamline's path. Streamlines are particularly useful for visualizing the overall direction of flow in a fluid system, and they provide an instantaneous representation of the flow's velocity field. In steady flow, where conditions do not change over...

Classification of Skeletal Muscle Fibers

Classification of Skeletal Muscle Fibers

Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...

Seedless Vascular Plants

Seedless Vascular Plants

Seedless Vascular Plants Were the First Tall Plants on Earth

What is Genetic Engineering?

What is Genetic Engineering?

Bernoulli's Equation for Flow Along a Streamline

Bernoulli's Equation for Flow Along a Streamline

Bernoulli's equation relates the energy conservation in a fluid moving along a streamline. The equation applies to incompressible and inviscid fluids under steady flow. For such a flow, Newton's second law is applied to a small fluid element, which experiences forces due to pressure differences, gravity, and velocity variations. The force balance leads to the following form of Bernoulli's equation: