老年人的状多巴胺和骨肌肉能量代谢
Caterina Rosano1, Nico I Bohnen2, Brian Lopresti1
1School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
概括
大脑中的多巴胺 (DA)
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 骨肌肉生理学 骨肌肉生理学
背景情况:
- 多巴胺 (DA) 是中枢神经系统中运动控制和能量的一个关键调节剂.
- 特别是在衰老中,DA和骨肌肉能量之间的确切关系仍然不太清楚.
研究的目的:
- 在老年人中调查条纹性多巴胺水平与骨肌肉线粒体功能之间的关联.
- 探索不同的条纹子区域如何与肌肉能量生产的体内和体外测量有关.
主要方法:
- 对146名老年人 (平均年龄为75.4岁) 的横截面研究.
- 使用 (+) -a-[11C]二二贝纳 (DTBZ) PET成像,量化了状DA.
- 在体内测量线粒体ATP生产 (ATPmax) 使用31P磁共振光谱;在体外测试评估线粒体呼吸.
主要成果:
- 用[11C]DTBZ测量的边缘纹状DA与更高的体内ATPmax (p=0.019) 有积极关联.
- 在多个混因素调整后,这种关联仍然很重要.
- 在[11C]DTBZ和ex vivo线粒体呼吸标志物 (p>0.2) 之间没有发现显著的关联.
结论:
- 在老年人中,边缘条纹性多巴胺可能在调节骨肌肉的体内能量容量方面发挥作用.
- 需要进一步的研究来阐明在老年人群中将边缘DA和肌肉能量联系在一起的特定机制.
相关概念视频
Classification of Skeletal Muscle Fibers
59.6K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.6K
Overview of Skeletal Muscle
15.0K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
15.0K
Relaxation of Skeletal Muscles
6.1K
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
6.1K
Disorders of the Skeletal Muscle
2.0K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.0K
Naming Skeletal Muscles
4.2K
The naming of the approximately 700 muscles in the human body is based on a set of criteria designed to provide descriptive information about each muscle, making it easier to identify and remember them.
The key factors used in naming muscles include:
The key factors used in naming muscles include:
4.2K
Skeletal Muscle Anatomy
92.9K
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
92.9K


