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相关概念视频

Endocrine Signaling01:45

Endocrine Signaling

68.3K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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Crossing Over01:34

Crossing Over

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Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
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What is the Endocrine System?00:46

What is the Endocrine System?

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The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
422.0K
The Endocrine System01:29

The Endocrine System

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The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
1.5K
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

14.4K
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
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Structures of the Endocrine System00:59

Structures of the Endocrine System

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The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
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相关实验视频

Updated: Feb 16, 2026

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
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In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

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基于图形的多模式交叉注意力框架,用于预测活体内分泌干扰物.

Eder Soares de Almeida Santos1, Gustavo Felizardo Santos Sandes1, Artur Christian Garcia da Silva2

  • 1Laboratory of Cheminformatics, Faculty of Pharmacy, Universidade Federal de Goiás, Goiás, Brazil.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 15, 2026
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概括

这项研究引入了用于内分泌危害评估的新AI框架,使用分子数据和生物通路信息准确预测生物体水平的结果. 该模型为监管毒理学提供透明,机械可解释的结果.

关键词:
负面结果的途径.类激素是一种类激素.深度学习是一种深度学习.内分泌干扰 干扰内分泌系统雌激素 雌激素 雌激素 是一种

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Methods to Test Endocrine Disruption in Drosophila melanogaster
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Methods to Test Endocrine Disruption in Drosophila melanogaster

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相关实验视频

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Methods to Test Endocrine Disruption in Drosophila melanogaster
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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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科学领域:

  • 计算毒理学和化学信息学
  • 内分泌干扰和危险评估
  • 不良结果路径 (AOP) 框架.

背景情况:

  • 准确和机械透明的模型对于内分泌危害评估至关重要.
  • 现有的方法往往缺乏透明度或需要进行广泛的体内试验.
  • 将分子数据与途径信息集成可以提高预测准确度.

研究的目的:

  • 开发一种多模式,交叉注意力图框架,用于预测生物体水平内分泌干扰结果.
  • 为了将分子图形与负面结果路径 (AOP) 固定的测试信号合并.
  • 提高内分泌危害评估的机制透明度.

主要方法:

  • 在Tier-1中利用多任务图形神经网络 (GNN) 来学习46个体外ToxCast/Tox21试验中的关键事件.
  • 在Tier-2中使用交叉注意的多式联网GNN来整合路径信号与分子图.
  • 应用双向交叉注意力和反事实性扰动来实现可解释性.

主要成果:

  • 在体内赫什伯格 (AUROC = 0.97 ± 0.014) 和子宫变 (AUROC = 0.97 ± 0.008) 试验中获得了高预测性能.
  • 对测试化合物的文献数据显示88%的一致性.
  • 确定了关键的分子亚结构和影响预测的测试.

结论:

  • 开发的框架准确地预测了内分泌干扰的结果,并具有机械解释性.
  • 这种方法支持化学安全评估的综合方法中的有针对性的测试策略.
  • 该模型提高了内分泌危害评估的透明度和准确性,与监管需求保持一致.