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ABO不兼容的血小板输血的安全性:一个多中心的回顾性队列研究
Abdulkerim Yildiz1, Samet Yaman1, Rafiye Çiftçiler2
1Department of Hematology, Faculty of Medicine, Hitit University, Erol Olçok Training and Research Hospital, Çorum, Türkiye.
与ABO兼容PC相比,ABO不兼容的血小板输血 (PC) 在输血反应率上没有显著差异. 然而,需要进一步的前性研究来确认ABO不兼容PC的安全性,特别是在资源有限的环境中.
科学领域:
- 输血医学 输血医学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 由于保质期短,ABO兼容的血小板缩剂 (PC) 并非总是可用.
- 血液中心必须制定使用ABO不兼容PC的策略.
- 关于ABO不兼容血小板输血的安全性存在相互矛盾的数据,特别是在输血反应方面.
研究的目的:
- 为了比较ABO兼容PC和ABO不兼容PC之间的输血结果.
- 确定与ABO不兼容PC相关的输血反应 (TR) 的发生率和类型.
- 评估ABO不兼容血小板输血的安全性.
主要方法:
- 多中心,回顾性队列研究分析了2016-2024年21,470次PC输血.
- 从血液监测系统和电子输血记录中提取的数据.
- 在ABO兼容和ABO不兼容的PC组之间比较TR率.
主要成果:
- 总共有21,470个PC被输血给了12,305名患者.
- 17个输血反应 (TRs) 发生 (0.79/1000个PC),主要是发烧性非溶血和过敏反应.
- 在ABO兼容和ABO不兼容的PC群体之间的TR率 (0.80对0.71每1000个PC) 或TR类型中没有显著差异 (P=0.88).
- 没有报告血液溶解反应.
结论:
- 虽然这项研究没有发现TR发生率的显著差异,但其追溯性质和低事件频率限制了关于安全性的最终结论.
- 在资源有限的环境中,ABO不兼容的PC可能是一个可行的选择.
- 需要进行更大规模的前性研究,使用标准化血清警,以确定ABO不兼容输血的安全性.
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