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Updated: Feb 16, 2026

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing
08:55

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing

Published on: January 20, 2023

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可电离性脂质纳米粒子和mRNA元素的综合工程,用于下一代疫苗

Jung Gi Kim1,2, Junchao Xu3, Dongjae Lee1

  • 1Nucleic Acid Therapeutics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang 28116, Republic of Korea.

ACS nano
|February 15, 2026
PubMed
概括

使用脂质纳米颗粒 (LNP) 的新型信使RNA (mRNA) 疫苗在低剂量时显示出更好的效力. 这项研究整合了脂质设计和未翻译区域 (UTR) 调整,以提高疫苗的疗效和向性输送.

关键词:
这是SARS-CoV-2 mRNA疫苗.通过白介导的运输.细胞内体逃脱的方法可离子化脂质是可以离子化的脂质.脂质纳米粒子 (LNP) 是一种淋巴结向的目标是淋巴结.未翻译的地区 (UTR)

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