肝移植患者的身体组成:长期变化和对康复结果的影响
Sofie Leunis1, Elias Desloovere1, Hanne Van Criekinge1
1Department of Microbiology, Immunology and Transplantation, Abdominal Transplantation, KU Leuven, Leuven, Belgium.
Clinical transplantation
|February 15, 2026
概括
肝移植 (LT) 后的肉症持续存在,影响了生存率. 不良的脂肪分布,特别是内脏脂肪,与更长的住院时间相关,这表明有针对性的管理对于改善结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植医学 移植医学
- 身体组成分析 身体成分分析
背景情况:
- 在等待肝移植 (LT) 的末期肝病 (ESLD) 患者中,肉症和肥胖是常见的.
- 这些情况通常在LT后持续存在,使康复复杂化.
- 身体质量指数 (BMI) 是ESLD中脂肪的不可靠指标;内脏和皮下脂肪组织 (VAT/SAT) 的比率是结果的更好的指标.
研究的目的:
- 为了研究 LT 后身体组成的长期变化.
- 检查前后LT体质组成与患者存活率之间的关联.
- 为了确定身体组成与住院/ICU停留时间之间的关系.
主要方法:
- 81名成年LT接受者的回顾性队列研究 (2009-2015).
- 身体组成 (骨肌指数,VAT,SAT) 通过CT/MRI评估在LT前的L3级和LT后的10年.
- 统计分析包括线性混合模型,生存分析和斯皮尔曼相关性.
主要成果:
- 在LT前,61%的患者是sarcopenic,19%的患者患有sarcopenic肥胖症.
- 在LT后,骨肌指数下降,但部分恢复;BMI最初下降,然后增加.
- 升高的LT前内脏脂肪组织 (VAT) 和VAT/SAT比率与长时间的ICU和住院住院有关.
结论:
- 石症在LT后长期持续存在,并与生存率降低有关.
- 不良的脂肪分布,特别是内脏脂肪,与医院资源利用率的增加有关.
- 建议早期识别和治疗肉类和内脏脂肪,以改善LT后的结果.
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