合成,表征,试验室和体内评价Pullulan-co-MAA水凝装饰5 - 甲,用于口腔结肠输送
Iqra Islam1, Kaleem Ullah2, Shujaat Ali Khan1
1Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan.
Current drug delivery
|February 15, 2026
概括
新的响应pH的水凝有效地将5-甲输送到结肠中. 这些pullulan-co-MAA水凝为结直肠癌提供了更安全的口服药物输送选择,显示出良好的耐受性和受控释放.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 传统的结直肠癌治疗会导致严重的副作用,影响患者的服从性.
- 由于其基于聚合物的性质,水凝作为口服药物输送载体提供了有利的替代品.
研究的目的:
- 为了合成针对结肠的,对pH值有反应的pullulan-co-MAA水凝,用于口服5-fluorouracil.
- 评估制造的水凝的体外和体内特征.
主要方法:
- 使用自由基聚合来合成pullulan-co-MAA水凝.
- 水凝的特点是交叉连接,药物结晶性,形态,凝含量,胀,多孔性和捕获效率.
- 在pH7.4下进行了体外药物释放研究,同时进行了细胞毒性和口服耐受性测试的MTT测试.
主要成果:
- 证实了成功的水凝形成与良好的5-甲捕获 (高达95.6%) 和增强的热稳定性.
- 药物释放取决于pH值,并受到聚合物,单体和交叉连接剂度的影响.
- 空白水凝显示出良好的细胞相容性 (>95%活力),而药物加载的水凝显示出剂量依赖的细胞毒性作用. 口服剂量高达4000mg/kg被很好地容忍.
结论:
- 合成的pullulan-co-MAA水凝显示出对5-fluorouracil的结肠向输送有前途的潜力.
- 这些水凝为口服药物输送提供了可行的替代方案,有可能改善患者在结直肠癌治疗中的服从性.
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