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三重阴性乳腺癌的新辅助化疗:乳腺和节点病理反应的系统审查

Milena Martello Cristófalo¹, Jonathan Yugo Maesaka¹, Deise Azevedo Pereira²

¹Institute of Cancer of the State of São Paulo, School of Medicine, University of São Paulo, São Paulo, Brazil.

Journal of surgical oncology

|February 15, 2026

概括

在接受新辅助化疗的三阴性乳腺癌 (TNBC) 患者中,淋巴结 (NpCR) 的病理完整反应比乳腺 (BpCR) 更常见. 这表明了未来研究遗漏手术评估的潜力.

科学领域:

在瘤学瘤学.
乳腺癌研究研究乳腺癌研究
化疗反应反应化疗反应

背景情况:

新辅助化疗后的病理完整反应 (pCR) 改善了三阴性乳腺癌 (TNBC) 患者的预后.
观察到的乳腺和下淋巴结之间的病理反应率的差异需要进行调查.
了解反应模式可能会为未来的策略提供信息,以省略手术评估.

研究的目的:

在TNBC患者中,系统地审查和比较乳腺病理反应 (BpCR) 和状淋巴结病理反应 (NpCR) 的患病率.
描述接受新辅助化疗的TNBC患者的反应模式.

主要方法:

按照PRISMA指南进行的系统审查,并在PROSPERO.中注册.
在PubMed,Embase和Web of Science数据库中进行的搜索.
包括在接受新辅助化疗的TNBC患者中报告NPCR和BpCR的研究;独立进行的文章选择和质量评估.

主要成果:

在所有包括的研究中,NPCR率始终高于BpCR率.
没有一项研究报告比NPCR更高的BpCR.
BpCR的平均患病率为32%,而NPCR的平均患病率为38.3%.

结论:

在接受新辅助化疗的TNBC患者中,NPCR比BpCR更频繁.
结果提供了对反应模式的描述性概述,可能指导未来关于省略手术评估的研究.
需要进一步的研究来确定预测生物标志物和优化治疗策略,因为超出瘤亚型的影响反应模式的因素.

关键词:

乳腺癌乳腺癌乳腺癌新辅助化学疗法新辅助化学疗法病理反应是一种病理反应.系统性审查系统性审查三重负的三重负.

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