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Bentuo Zhang¹, Yinkui Wang¹, Bin Yu¹

¹Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Cancer Center, Peking University Cancer Hospital & Institute, Beijing, 100142, China.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

|February 15, 2026

概括

对于节点阴性胃癌 (GC) 患者来说,在胃切除术期间检索至少16个淋巴结是足够的. 提取的淋巴结数量 (NRLNs) 超过这一值,并不能提高整体存活率或无病存活率.

科学领域:

手术瘤学手术瘤学
胃肠道瘤学胃肠道瘤学
癌症研究癌症研究

背景情况:

激进胃切除术指南建议至少有16个淋巴结进行充分的淋巴切除术.
在节点阴性胃癌 (GC) 中,增加提取的淋巴结数量 (NRLNs) 超过16个的生存益处尚不清楚.

研究的目的:

为了确定节点阴性胃癌 (GC) 患者获取的淋巴结 (NRLNs) 的最佳数量.
调查是否增加NRLN超过16节能改善节点阴性GC的生存结果.

主要方法:

对1264名GC患者的临床病理学数据 (2007-2022) 的回顾性分析.
限制立方线 (RCS) 分析以确定NRLN的切线值.
卡普兰-梅尔和考克斯的比例危险模型来评估整体生存率 (OS) 和无疾病生存率 (DFS).

主要成果:

在pN0 (病理结节阴性) 患者中,NRLNs与OS或DFS没有相关性.
在cN0 (临床结节阴性) 患者中,NRLNs>30显示出与更糟糕的生存状况的单变体关联,但这在多变体分析中并不显著.
根据pN阶段进行的子组分析显示,在cN0患者中,不同类别的NRLN之间,在OS或DFS中没有显著差异.

结论:

至少16个提取的淋巴结 (NRLNs) 似乎足够的节点阴性胃癌 (GC) 患者接受激进胃切除术.
进一步增加NRLN超过16并没有为节点阴性GC患者提供额外的生存益处.

关键词:

胃癌胃癌是指胃癌.淋巴管切除术是指淋巴管切除术.这是一个节点负的节点.提取的淋巴结的数量.

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