模拟和实验研究的温度控制在周脉磁感应高温基于多库里温度的热种子
Zhuoyang Li1, Yanyong Ye1, Xin Fu2
1South China University of Technology, Guangzhou, 510000, China.
Journal of thermal biology
|February 15, 2026
概括
这项研究介绍了肝脏瘤磁性高温症的区域控制策略,使用独特的基里温度材料精确准瘤,同时保护健康组织免受热. 该方法克服了血管化瘤中血液流动所带来的挑战.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 医学物理 医学物理
背景情况:
- 血管冷却在肝脏瘤磁性高温症期间对温度均分布提出了挑战.
- 有效的热除需要精确的温度控制,特别是在高度血管化的瘤中.
研究的目的:
- 开发和验证针对肝脏瘤的向磁性高温症的区域控制策略.
- 研究血管结构和血液流动对温度分布的影响.
- 评估使用具有不同基里温度的磁介质进行热控制的有效性.
主要方法:
- 构建一个多物理结合模型的肝脏瘤与Y形血管结构.
- 模型的验证使用ex vivo组织实验.
- 在交替磁场下模拟温度场分布,分析血液流速,血管分叉角度和血管直径的影响.
主要成果:
- 区域控制策略在瘤核心 (高达71.7°C) 中实现了精确的热除.
- 周周血管区域 (∼38.5°C) 保持安全温度,瘤边缘 (43°C) 有效高温.
- 发现磁场强度与频率相比,对温度升高具有主导影响.
结论:
- 拟议的区域控制策略有效地克服了肝脏瘤中的血管散热挑战.
- 这种方法为高度血管化的瘤中安全和向的高热量提供了理论和实验基础.
- 使用具有不同基里温度的磁介质,可以在高温治疗过程中精确地进行热管理.
相关概念视频
01:16Specific Heat
The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or 4186 J/kg/K.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or 4186 J/kg/K.
02:45Responses to Heat and Cold Stress
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
01:25Increased Body Temperature
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
01:22Methods of reducing fever
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
01:19Homeostatic Imbalances in Body Temperature
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
01:23Physical Methods for Controlling Microbial Growth: Temperature
Heat is a widely used method to control microbial growth by targeting and denaturing cellular proteins, thereby killing or inactivating microbes. This method's effectiveness is quantified using parameters such as the thermal death point (TDP), thermal death time (TDT), and decimal reduction time (D value). TDP represents the lowest temperature at which all microorganisms in a liquid suspension are eliminated within 10 minutes, whereas TDT is the time necessary to achieve sterilization at a...