粉纳米颗粒上的氨酸和氨酸冠状:依赖于大小的黄素释放和生物活性的调节
Zhiheng Zhang1, David Julian McClements2, Hangyan Ji1
1State Key Laboratory of Food Science and Resources, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, Jiangsu 214122, China.
Food chemistry
|February 15, 2026
概括
较小的黄素载粉纳米颗粒增强蛋白质冠状形成与消化酶,如素和素. 这种相互作用影响了酶活性,为改善基于多的输送系统的生物可用性提供了见解.
科学领域:
- 纳米技术纳米技术
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
背景情况:
- 了解纳米粒子-蛋白质相互作用对于药物输送系统至关重要.
- 基于多的纳米颗粒显示出增强生物可用性的承诺.
- 消化酶可以在体内改变纳米粒子的行为.
研究的目的:
- 为了研究黄素载粉纳米颗粒大小对蛋白质冠状形成的影响.
- 分析纳米粒子,素和素之间的相互作用.
- 为了评估蛋白质冠状病毒如何影响酶活性和黄素封装.
主要方法:
- 扫描电子显微镜 (SEM) 和原子力显微镜 (AFM) 用于纳米粒子形态学.
- 福里埃变换红外 (FTIR) 和光光谱学用于相互作用分析.
- 用于黄素封装的X射线衍射 (XRD).
- 石英晶体微平衡与分散监测 (QCM-D) 用于吸附研究.
主要成果:
- 纳米粒子呈现出球形的形状.
- 蛋白质冠状形成是由疏水相互作用和结合驱动的.
- 更小的纳米粒子促进了更紧密的酶吸附,增加了蛋白质冠状形成.
- 库尔库明封装保持稳定,尽管酶冠状形成.
- 素活性稳定,而素活性随着纳米粒子大小的增加而增加.
结论:
- 纳米粒子大小显著影响蛋白质冠状形成和消化酶相互作用.
- 在与纳米颗粒相互作用时,发生了酶特异性构造适应.
- 结果为设计基于多的纳米颗粒提供了洞察力,以提高生物可用性.
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