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综合生物信息学识别了与LPS代谢和昼夜干扰相关的NSCLC生物标志物

Yu Chen¹, Yifan Zhao², Qinghua Kong³

¹Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Translational oncology

|February 15, 2026

概括

这项研究揭示了与脂多糖 (LPS) 代谢和昼夜干扰相关的非小细胞肺癌 (NSCLC) 的新基因特征. CACNA2D2作为瘤抑制剂,为早期NSCLC检测和向治疗提供了潜力.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
分子生物学分子生物学

背景情况:

非小细胞肺癌 (NSCLC) 是癌症死亡的主要原因.
脂聚糖 (LPS) 代谢和昼夜节律扰乱与癌症有关,但它们在NSCLC中的作用尚不清楚.

研究的目的:

确定与LPS代谢和昼夜节律相关的NSCLC相关基因.
确定这些基因的诊断潜力.
研究候选基因在NSCLC进展中的功能.

主要方法:

综合多个基因表达数据集 (GEO).
利用权重基因共同表达网络分析 (WGCNA) 和机器学习 (Lasso,随机森林) 来识别枢纽基因.
在CACNA2D2.2.上进行了免疫透分析和功能实验 (功能增加/丧失).

主要成果:

鉴定了889个与炎症和免疫相关的差异表达基因 (DEGs).
WGCNA强调了一种与血管生成和细胞外矩阵组织相关的红模块.
包括CACNA2D2在内的9个枢纽基因表现出强大的诊断性能 (AUC 0.832-0.906) 并与免疫透相关.
CACNA2D2作为一种瘤抑制剂,抑制NSCLC细胞活力,增殖,迁移和入侵.

结论:

确定了一种与LPS代谢和NSCLC中昼夜干扰相关的新型基因特征.
这种签名具有诊断效用,并影响瘤免疫调节.
CACNA2D2是一种关键的瘤抑制剂,为早期检测和治疗提供了潜在的点.

关键词:

循环节律的破坏循环节律的破坏脂多糖 (LPS) 的代谢非小细胞肺癌 (NSCLC) 是一种非小细胞肺癌.有针对性的治疗.瘤的免疫微环境

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