由螺旋仪 sp. 引起的脑菌病. :一个案例报告
1Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Diagnostic microbiology and infectious disease
|February 15, 2026
概括
甲基因组下一代测序 (mNGS) 成功诊断了一名患有非特异性症状的患者的罕见脑性斯帕尔加诺सिस. 这种先进的诊断工具有助于识别具有挑战性的寄生虫感染,如Spirometra sp.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 寄生虫学的寄生虫学
背景情况:
- 大脑斯帕尔加诺斯是一种罕见的寄生虫感染,由Spirometra幼虫感染,呈现非特异性症状,使诊断复杂化.
- 这种情况可能导致渐进的神经缺陷,包括认知衰退和视觉障碍.
研究的目的:
- 报告一位年长的女性脑病的具有挑战性的病例.
- 突出元基因组下一代测序 (mNGS) 在诊断罕见的寄生虫中枢神经系统感染方面的实用性.
主要方法:
- 一名72岁的女性有间歇性发烧和迁移性内病变史,接受了脑脊液 (CSF) 分析.
- 甲基因组下一代测序 (mNGS) 在CSF和大脑活检样本上进行.
- 这名患者接受了普拉齐昆和阿尔本达治疗.
主要成果:
- CSF的mNGS确定了Spirometra sp.,导致诊断为大脑斯帕尔加诺症.
- 脑病变活检和随后的组织mNGS证实了寄生虫感染.
- 患者在用普拉齐昆和阿尔本达治疗抗寄生虫药物后显示出显著的临床改善.
结论:
- 下一代元基因组测序是诊断大脑斯帕尔加诺症非典型表现的一个有价值的工具.
- 使用mNGS进行早期和准确的诊断可以导致有效的治疗和改善患者的治疗结果.
- 这一案例强调了在患有无法解释的神经症状的患者中考虑罕见的寄生虫感染的重要性.
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