表皮状纤维细胞瘤涉及深层皮肤和皮下脂肪组织
Anum Dileep1, Shawn E Cowper2,3, Gauri Panse2,3
1Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, Connecticut, USA.
Journal of cutaneous pathology
|February 15, 2026
概括
在上皮状纤维性囊细胞瘤 (EFH) 中,皮肤深部卷入是罕见的. 这项研究强调了深层皮肤中三种结节性EFH的病例,强调了ALK免疫组织化学用于诊断.
科学领域:
- 皮肤病理学 皮肤病理学
- 在瘤学瘤学.
- 历史学 历史学 历史学
背景情况:
- 表皮状纤维性囊细胞瘤 (EFH) 通常在表面皮肤中呈现,带有表皮.
- 深层皮肤或皮下干扰是EFH的一种不常见的表现.
研究的目的:
- 描述三种结节性表皮状纤维性囊细胞瘤的病例,涉及深层皮肤和皮下组织.
- 强调ALK免疫组织化学在识别EFH异常变异的诊断实用性.
主要方法:
- 对三个结节性病变进行了组织病理学检查.
- 细胞形态的分析,包括带有囊状细胞核和eosinophilic细胞质的上皮状细胞.
- 应用ALK免疫组织化学来评估细胞标记模式.
主要成果:
- 这三个病例都表现出深层皮肤/皮下结节.
- 观察到特征性上皮状细胞特征和ALK免疫反应活性.
- 病变范围从0.8到2.0厘米,在成年人身上发生在干部或四肢上.
结论:
- 这些病例扩大了已知的表皮状纤维性囊细胞瘤的形态谱.
- ALK免疫组织化学对于区分深层皮肤EFH变体与模仿者至关重要.
- 长期随访 (4.5-23年) 显示在所述病例中没有复发.
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