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准稳定状态CEST用于快速和定量检测多发性硬化症中的病变在3T时

Huabin Zhang¹, Ziyan Wang², Shihao Zeng²

¹Medical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, China; Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Brain research bulletin

|February 15, 2026

概括

几乎稳定状态 (QUASS) CEST MRI显著减少了多发性硬化症 (MS) 诊断的扫描时间. 这种方法保持了病变的对比性,并揭示了脱髓化,有助于MS监测和治疗评估.

科学领域:

生物医学成像技术生物医学成像技术
磁共振成像技术磁共振成像技术
神经成像是一种神经成像.

背景情况:

化学交换和转移 (CEST) 核磁共振是多发性硬化症 (MS) 诊断和复髓化监测的有价值的.
定量CESTMRI面临的挑战是扫描参数变化和长和时间.
优化扫描效率对于临床适用性至关重要.

研究的目的:

研究准稳态 (QUASS) CEST MRI在3T的实用性,以减少MS的扫描时间.
为了评估 QUASS 校正的定量测量,以保持一致的损伤对比度.
评估 QUASS 对在 MS 检测特定 CEST 效应的影响.

主要方法:

数字模拟和体内实验与健康志愿者和MS患者.
将 QUASS 处理应用于在 3T.获得的 CEST MRI 数据.
使用5池洛伦兹拟合,分离了五个CEST效应 (胺,CEST@2ppm,MT,rNOE,DS).

主要成果:

QUASS有效地消除了和时间的依赖性,并在模拟中提高了CEST@2ppm的检测能力.
在体内实验中,MS病变的高对比度与使用QUASS的46.7%的扫描时间缩短.
经过 QUASS 校正的 CEST 显示了减少 rNOE 和 MT 与脱髓化形成鲜明对比,而胺则减少了病变,而 CEST@2ppm 显示了MS病变的显著减少.

结论:

准胸部MRI为MS的定量成像提供了一个更快,更强大的方法.
该技术提供了关于MS病变中脱髓化和蛋白质损失的见解.
在临床MS诊断和治疗评估方面,QUASS-CEST具有显著的潜力.

关键词:

化学交换和转移 (CEST) 是一种损伤检测检测损伤的检测运动校正,运动校正.多发性硬化症 (MS) 是一种疾病.准稳定状态 (QUASS) 的情况.

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