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在老年医院的废水基础上对呼吸道病毒的监测:试点研究

Rebecca Grant¹, Marie-Céline Zanella¹, Charles Gan²

¹Infection Control Programme and WHO Collaborating Centre, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

The Journal of hospital infection

|February 15, 2026

概括

基于废水的监测 (WBS) 在瑞士一家医院有效监测了SARS-CoV-2,流感和RSV,显示出与患者感染的显著相关性. 在医疗保健机构内,WBS可以作为呼吸道病毒的早期预警系统.

科学领域:

环境微生物学环境微生物学
传染病流行病学传染病流行病学
公共卫生监督是对公共卫生的监督.

背景情况:

建立了基于废水的监测 (WBS),用于社区监测病原体.
医院环境中的WBS应用存在有限的数据.
了解医院中的病原体动态对于感染控制至关重要.

研究的目的:

评估WBS用于追踪SARS-CoV-2,流感A/B和RSV在老年医院中的情况.
为了将医院废水的病毒负载与患者感染数据相关联.
评估WBS作为医疗机构的早期预警系统.

主要方法:

未来WBS研究收集每日废水样本.
通过数字RT-PCR对SARS-CoV-2,流感A/B和RSVRNA进行量化.
使用肯德尔的等级相关性和交叉相关性函数进行统计分析.

主要成果:

在废水病毒载荷和患者感染SARS-CoV-2,A型流感和RSV之间发现了显著的正相关性.
在医疗保健相关的感染中,关联仍然很重要.
废水病毒载量增加了临床病例检测前的3-5天.

结论:

呼吸系统系统 (WBS) 是监测医院呼吸系统病毒循环的可行工具.
WBS可以作为医疗保健相关感染的补充早期预警系统.
这种方法增强了医院的感染控制策略.

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