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Updated: Feb 17, 2026

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2014-2024年新生儿败血症:2014-2024年新生儿败血症:格拉姆阴性杆菌的复苏
Noa Fleiss1, Thomas S Murray1, Richard S Feinn2
1Department of Pediatrics, Yale School of Medicine, New Haven, CT; Yale New Haven Children's Hospital, New Haven, CT, USA.
The Journal of pediatrics
|February 15, 2026
概括
新生儿败血症显示了格拉姆阴性病原体的增加,特别是大肠杆菌,导致死亡率增加. 这一趋势,加上更低的妊娠年龄和更高的疾病严重程度,影响新生儿重症监护室 (NICU) 的结果.
科学领域:
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 新生儿败血症仍然是全球疾病和死亡的重要原因.
- 了解不断变化的病原体趋势和风险因素对于改善新生儿结果至关重要.
研究的目的:
- 评估新生儿败血症发病率,病原体,临床特征和2014-2024年的结果.
- 将当前数据与历史机构记录进行比较.
- 分析自1928年以来新生儿败血症的长期趋势.
主要方法:
- 对患有血流感染的婴儿进行回顾性队列研究 (2014-2024年).
- 展望事件记录和回顾性数据收集.
- 单变量和多回归分析,比较两个时代 (2004-2013年与2014-2024年).
主要成果:
- 在233名婴儿 (2014-2024) 中发生了250次败血症.
- 在早期发作的败血症 (EOS) 中增加了阳性生物体,特别是大肠杆菌,特别是在晚期早产/晚期新生儿和VLBW婴儿中.
- 晚发性败血症 (LOS) 的发病率较低,但严重程度和死亡率增加 (11%至25%),グラム阴性细菌增加到50% (2020-2024年).
- 三十年来,与败血症相关的死亡率稳步增加;预测因素包括出生体重较低,压力器使用,NEC和血栓塞缩小.
结论:
- 持续增加的格拉姆阴性病原体,特别是大肠杆菌,对于EOS和LOS.
- 降低妊娠年龄和增加基线疾病严重程度有助于增加与败血症相关的死亡率.
- 迫切需要采取战略来应对新生儿败血症流行病学的变化.
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