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基于PROTAC和HyTTD技术的RET蛋白降解的设计,合成和活动评估

Ning Xu1, Yunmeng Zhao2, Jinfeng Liu1

  • 1Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Bioorganic & medicinal chemistry letters
|February 15, 2026
PubMed
概括

研究人员开发了一种新型的疏水性标签结合降解剂 (HyTTD),以准和降解RET融合蛋白,为RET驱动的癌症提供了新的治疗策略,这些癌症对当前治疗有抗性.

关键词:
疏水性标签绑定降解剂降解剂针对蛋白质溶解的嵌合体.在转染过程中重新排列.有针对性的蛋白质降解降解.

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