失去了cystathionine-β-synthase有助于增加OXPHOS,这是一种在唐氏综合征中对Ara-C抗性髓性白血病的脆弱性

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Jenna Thibodeau1, Jianlei Zhao2, Holly Edwards2

  • 1Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI, USA.

Biochemical pharmacology
|February 15, 2026
PubMed
概括

囊氨酸β合成酶 (CBS) 调节氧化酸化 (OXPHOS) 和细胞arabine (Ara-C) 响应在氏综合征 (ML-DS) 的骨髓性白血病. 针对OXPHOS和亡,为复发性/耐药性ML-DS提供了一个有前途的治疗方法.

关键词:
耐Arac-C的抗氧化物.这是CBS的CBS.囊氨酸-β-合成酶的使用.硫化是一种硫化.在ML-DSDS上,奥克斯福斯 (OXPHOS) 是一个

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