在心脏起器刺激过程中,大脑前皮层和血中诺拉丁上腺素水平的增加大脑血流
Hideaki Suzuki1, Shunsuke Tatebe1, Tomoki Irino1
1Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine.
概括
心脏电刺激激活大脑区域,包括前带带皮层 (ACC),并增加诺亚上腺素水平. 该ACC似乎处理心脏信号,影响节奏节奏期间的自主性兴奋.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 医疗成像医学成像
背景情况:
- 胸痛等胸部症状在心血管疾病中很常见.
- 关于大脑处理心脏 afferent 信息的研究是有限的.
研究的目的:
- 在心电刺激期间调查大脑活动的变化.
- 识别参与处理心脏 afferent 信号的大脑区域.
主要方法:
- 10名带有起器的患者接受了脑部H215O-PET扫描.
- 扫描是在假冒和电刺激节奏时进行的.
- 测量了区域大脑血流 (rCBF) 和血诺上腺素.
主要成果:
- 电刺激增加了前带带皮质 (ACC),后带带皮质,前额皮质,乳头,杏仁体和中脑中的rCBF.
- 在刺激过程中,ACC rCBF和血诺上腺素水平显著升高.
- 在ACC rCBF和血诺上腺素之间发现了正相关性.
结论:
- 心脏电刺激增强了ACC中的rCBF,并增加了血的诺亚上腺素.
- ACC可以作为处理心脏 afferent 信息的中心枢纽.
- 这种处理有助于在心脏节拍过程中自主激发.
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