开发一种带有生提取物的自我纳米乳化药物输送系统,以提高生提取物的可溶性
Maung Maung Than1, Chuda Chittasupho2, Songwut Yotsawimonwat2
1Ph.D. Degree Program in Pharmacy, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
Drug discoveries & therapeutics
|February 15, 2026
概括
这项研究开发了一种自我纳米乳化药物递送系统 (SNEDDS),以改善生提取物.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 自然产品化学 自然产品化学
- 材料科学 材料科学 材料科学
背景情况:
- 生 (Zingiber officinale) 具有健康益处,但其活性化合物6-生醇的溶解性和稳定性较差.
- 提高口服输送对于最大限度地发挥生的治疗潜力至关重要.
研究的目的:
- 制定一种自纳米乳化药物输送系统 (SNEDDS),以改善生提取物的口服输送.
- 使用实验设计 (DoE) 方法优化SNEDDS配方,以提高6-醇的可溶性和稳定性.
主要方法:
- 使用超声波辅助提取方法获得生提取物,优化了6-生醇含量.
- 使用I-最佳混合物设计开发SNEDDS,使用麻油,Cremophor RH40,共同表面活性剂 (Span 20/80),以及共同溶剂 (PEG 400/乙醇).
- 描述包括滴滴大小分析,封装效率,体外释放研究和传输电子显微镜 (TEM).
主要成果:
- 优化的SNEDDS在胃介质中很容易形成纳米乳液 (42.5-78.1nm).
- 用生提取物加载的SNEDDS (G-SNEDDS) 实现了为6-gingerol和6-shogaol的封装效率>90%.
- 在实验室中,从G-SNEDDS中释放的6-甘醇在48小时内达到~90-100%,明显高于未配制的提取物 (67%).
- TEM证实了统一的,球形的纳米乳液滴.
- 该配方在环境条件下表现出良好的短期稳定性,尽管高温加速了6 - 银醇转化为6 - 糖醇的转化.
结论:
- 开发的SNEDDS显著提高了生提取物的可溶性,溶解性和稳定性.
- 这种配方为改善生活性化合物的口服生物可用性提供了一个有希望的策略.
- 需要进一步研究长期稳定性和体内疗效.
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