[尽管直接服用口服抗凝药,但心房动相关的缺血性中风导致皮肤穿透的左心房尾关闭:病例报告]
Kenshin Kawabata1, Shuhei Egashira1, Kyosuke Muramatsu1
1Department of Neurology, Toranomon Hospital.
Rinsho shinkeigaku = Clinical neurology
|February 15, 2026
概括
这项研究表明,左心房尾阻塞 (LAAO) 可以成为心房动患者的有效二次中风预防策略,这些患者尽管接受抗凝治疗,但仍患有缺血性中风.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗器械 医疗器械
背景情况:
- 非膜性心房动增加了中风风险.
- 抗凝药是标准治疗,但突破性中风也会发生.
- 左心房附属体 (LAA) 是心血管血栓性中风的常见来源.
研究的目的:
- 评估皮左心房尾闭塞 (LAAO) 在二次中风预防中的疗效.
- 评估LAAO在患有复发性缺血性中风的患者的安全性和有效性,尽管服用抗凝药.
主要方法:
- 一个79岁的妇女的病例报告,患有非膜心房动和心血管栓塞性中风.
- 患者正在接受埃多克萨班治疗.
- 通过脑磁共振成像和食道横断心声图 (TEE) 证实了诊断.
- 患者在继续服用edoxaban.com的同时接受了皮肤穿透的LAAO.
主要成果:
- 大脑MRI证实了急性缺血性心脏病发作.
- 在LAA中,TEE揭示了自发的回声对比度和减少的流速.
- 患者在LAAO后没有出现复发性缺血性中风或设备相关的血栓形成.
- 临床过程并不复杂.
结论:
- 通过皮肤注射的LAAO,当添加到抗凝药时,可能是选择性心房动患者中继性中风预防的可行选择.
- 尽管最佳的抗凝血疗法,LAAO为患有缺血性中风的患者提供了潜在的解决方案.
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