肠道微生物群作为自身免疫和免疫介导性关节炎的生物治疗中的生物标志物和标 - - 一项系统性审查
Madhumitha Rondla1, Mohamed Sayed Zaazouee2, Arya Akhila Perumangote Vasudevan3
1M. Rondla, MD, Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.
The Journal of rheumatology
|February 15, 2026
概括
生物疗法在自身免疫性关节炎中改变肠道微生物群,促进有益细菌并减少有害细菌. 特定的微生物可以作为治疗成功和疾病活性的生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群失调与自身免疫性关节炎的发病有关.
- 生物可能会影响肠道微生物群,但机制 (直接与间接) 尚不清楚.
- 了解对肠道微生物群的生物学影响对于治疗优化至关重要.
研究的目的:
- 系统地审查生物疗法如何调节自身免疫性关节炎的肠道微生物群.
- 探索肠道微生物群作为治疗反应和疾病活性生物标志物的潜力.
主要方法:
- 在PubMed,Scopus,Cochrane图书馆和Web of Science的系统文献搜索.
- 包括评估免疫介导或自身免疫性关节炎中生物治疗诱导的肠道微生物群变化的研究.
- 结果侧重于微生物群的变化及其作为预测生物标志物的潜力.
主要成果:
- 十二项研究表明,生物药物 (抗TNF,IL-17抑制剂) 改变了肠道微生物群的组成和多样性.
- 治疗增加了α多样性,并使β多样性正常化,恢复有益的种群 (例如,Faecalibacterium prausnitzii) 并减少炎症性基因.
- 像Lachnospiraceae和Megamonas这样的特定种群与临床改善和疾病活性降低相关.
结论:
- 生物疗法将肠道微生物群转移到自身免疫性关节炎中的eubiosis.
- 某些微生物种群 (Lachnospiraceae,Blautia,Faecalibacterium prausnitzii) 显示出作为非侵入性生物标志物的承诺.
- 需要进一步的研究来验证微生物签名的临床应用.
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