皮素-胺素与单独的皮素对B组阴性链球菌患者的长期产前膜破裂:一种随机对照试验
Raneen Abu Shqara1, Daniel Glikman2, Gabriela Goldinfeld2
1Department of Obstetrics & Gynecology, Galilee Medical Center, Nahariya, Israel; Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
American journal of obstetrics and gynecology
|February 15, 2026
概括
在长期膜破裂 (PROM) 预防中,添加甘他素和安皮西林显著减少了没有B型 estreptococcus (GBS) 定居的妇女的母体感染,如胆炎和产后发病率. 这种组合治疗提供了更好的结果.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 产前延长的膜破裂 (PROM) 增加了孕妇和新生儿感染的风险.
- 在女性中PROM的最佳预防性抗生素策略,B组链球菌 (GBS) 殖民是负面的,尚未明确定义.
研究的目的:
- 为了比较两个预防性抗生素治疗方案的孕产妇和新生儿结局:安培素加上 gentamicin 与单独安培素.
- 为了评估这些治疗方案在患者的期末PROM和证实消极的GBS定居.
主要方法:
- 一个单一中心随机对照试验,涉及207名女性的期 PROM (≥18小时破裂) 和负GBS状态.
- 参与者接受了静脉注射安皮西林加热胺素或单独安皮西林,在断裂后18小时开始.
- 共同初级结局包括临床膜炎和子宫内膜炎;二级结局评估了孕产妇和新生儿感染以及住院时间.
主要成果:
- 西林 - 珍塔米辛组的临床胆 ?? 肌炎 (1.9%vs10.6%) 和整体产后感染性发病率 (1.9%vs9.6%) 显著降低.
- 在不同组之间,子宫内膜炎的发病率相似.
- 新生儿重症监护病房的入院,怀疑早期发作的败血症和阳性膜细胞培养,在安培 - 甘他手臂减少.
结论:
- 预防性安皮西林加上 جنت米辛在降低临床肌炎和产后孕产妇传染性发病率方面比安皮西林单疗更有效,在具有负GBS定居的终期PROM患者中.
- 珍塔素所提供的增强的格拉姆阴性覆盖率可能有助于改善母亲的结果.
- 需要进一步的研究来评估更广泛的格兰氏阴性覆盖在这种患者群体中的好处.
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