睡前Delta-9-Tetrahydrocannabinol (THC):关于睡眠和心脏自主活动的可行性和机制试点研究
Joshua E Gonzalez1,2, Alicia V Stewart1, Jacquelin L Ellison1
1Oregon Institute of Occupational Health Sciences, Oregon Health and Sciences University, Portland, Oregon, USA.
Journal of sleep research
|February 15, 2026
概括
睡眠前的急性 Δ9 - 四大麻素 (Δ9 -THC) 给药会增加皮质激活,并减少心脏的副交感活动. 这项研究发现,在常规的大麻使用者中,Δ9THC扰乱了睡眠和心率的变化.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 睡眠医学 睡眠医学
背景情况:
- 睡眠障碍是大麻使用的常见原因,但THC对睡眠和自主调节的影响尚未完全理解.
- 虽然急性-THC可能促进睡眠,但慢性使用与睡眠障碍和潜在的心血管风险有关.
研究的目的:
- 为了检查急性D9THC对常规和最小大麻使用者的睡眠和心脏副交感活动的影响.
- 为了评估在实验室环境中控制 Δ9 -THC 的可行性和耐受性.
主要方法:
- 一项试点研究涉及18名成年人 (9名常规大麻使用者,9名最低暴露) 进行了为期2周的睡眠稳定.
- 三个夜晚的实验室协议:适应,安慰剂和10毫克口服 Δ9 -THC.
- 通过多睡眠学和动图学监测睡眠;通过心率变化评估心脏自主活动.
主要成果:
- 在家庭监测期间,经常使用大麻的用户表现出更短的总睡眠时间和更大的睡眠障碍.
- -THC增加了睡眠延迟,慢波睡眠和EEG光谱功率,同时减弱了三角洲功率消散.
- Δ9 -THC在时间和频率领域显著降低了心率变化.
结论:
- 控制的 Δ9 -THC 给药在成年人中是可行的和可以容忍的,无论大麻使用史.
- 睡前急性 Δ9 -THC 增加皮质激活,并在睡眠期间降低心脏副交感活动.
- 这些发现提供了对-THC对睡眠和自主功能的复杂影响的初步机制性见解.
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