一种简单的多糖液凝通过肠轴激活PPARγ,以改善慢性病
Zhuowen Liang1,2, Ali Chen3, Huimin Lin4
1Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Journal of nanobiotechnology
|February 15, 2026
概括
一种新的水凝将Morinda officinalis多糖 (MOP) 和胰岛素输送到结肠,恢复肠轴. 这种向治疗改善了肠道微生物群,减少了炎症,并在慢性病 (CKD) 中保护脏.
科学领域:
- 生物材料科学 生物材料科学
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 慢性病 (CKD) 涉及肠道微生物群失调,炎症和肠道屏障功能受损,突出显示肠轴.
- 来自植物的多糖体显示出脏保护的潜力,但面临着诸如有限的结肠暴露和近端发酵等挑战.
- 需要一个有针对性的交付系统来克服这些限制,以便有效地管理CKD.
研究的目的:
- 设计一种针对结肠的,由Morinda officinalis多糖 (MOP) 和胰岛素组成的复合水凝 (MI Gel),用于CKD治疗.
- 在CKD小鼠模型中评估水凝的持续释放,粘膜粘附和对肠轴的治疗作用.
主要方法:
- 使用绿色热水制造工艺制造了MOP/胰岛素复合水凝 (MI Gel).
- 在CKD小鼠中评估了水凝的肠内保留,微生物群调节,代谢物产生和信号通路激活.
- 评估了对炎症性细胞因子,活性氧物种 (ROS),淋巴细胞功能和纤维化的影响.
主要成果:
- 在CKD小鼠中,MI Gel表现出耐降解性和长时间的肠保持性.
- 水凝重新塑造了肠道微生物群,增加了有益的细菌 (Muribaculaceae,Allobaculum),并增加了短链脂肪酸 (propionate,butyrate).
- 与自由多糖相比,MI Gel治疗减少了炎症性细胞因子 (TNF-α,IL-6,IL-1β),ROS,改善了淋巴细胞功能和减弱了纤维化.
结论:
- 针对结肠的,抗酸的MI Gel有效地通过协同的MOP和胰岛素发酵恢复了肠轴的平衡.
- 这种工程水凝为治疗慢性病提供了可行的长期治疗策略.
- 这项研究强调了先进生物材料在调节肠道微生物群以进行保护方面的潜力.
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