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在克拉化样本中检测phenibut:一个验证和案例研究

Amy Racines¹, Joseph Jones¹, Ming Wang²

¹United States Drug Testing Laboratories, Des Plaines, IL, USA.

Journal of analytical toxicology

|February 15, 2026

概括

一种新方法可以在头发和指甲中检测到Phenibut (β--γ-黄油酸). 这项经过验证的法医毒理学试验证实了Phenibut在自我报告的用户中的使用,为血液或尿液测试提供了替代方案.

科学领域:

法医毒理学法医毒理学
分析化学分析化学

背景情况:

费尼布特 (β--γ-黄油酸) 是一种中枢神经系统抑制剂,具有显著的不良影响,导致其在许多地区未被批准用于医疗用途.
测试的有限可用性阻碍了对Phenibut在美国的公共卫生影响的理解.

研究的目的:

验证一种新型的分析方法,用于检测Phenibut在质化标本 (头发和指甲) 中.
用验证的方法分析自报告Phenibut用户的头发和指甲样本.

主要方法:

固体相提取 (SPE) 随后进行液体染色学-并联质谱学 (LC-MS/MS).
方法验证根据法医毒理学ANSI/ASB标准036进行验证.

主要成果:

分析方法已成功验证,符合所有要求的标准.
尼布特在头发和指甲样本中检测到的度超过了线性的上限 (>4000 pg/mg).
这标志着Phenibut在头发和指甲样本中检测到的第一个报告.

结论:

经过验证的SPE-LC-MS/MS方法可以在头发和指甲中检测Phenibut.
克拉化样本为Phenibut监测提供了一个有希望的,不那么侵入性的替代方案.
用户的积极检测突出了需要可访问的Phenibut测试方法.

关键词:

在 LCMSMSMS 的情况下.一个指甲的指甲.头发头发头发头发头发克拉化样本的样本.液态色谱学双重质谱学质谱学钉钉钉的钉子钉钉的钉子.现象,但却是一种现象.

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