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在现实世界中转移性乳腺癌的结果:在前性数据集中分析长期生存和治愈能力

Arlene Chan¹, Mengdie Zhou², Mridula Arun³

¹Breast Cancer Research Centre-WA and Curtin University, Perth, WA, Australia.

|February 15, 2026

概括

转移性乳腺癌 (MBC) 患者可以实现长期生存和潜在的治愈,即使在临床试验之外. 现实世界的数据表明,持久的反应是可能的,为治愈不治愈的疾病管理提供了乐观的希望.

科学领域:

在瘤学瘤学.
医学统计医学统计
临床研究临床研究

背景情况:

尽管生存率有所改善,转移性乳腺癌 (MBC) 仍然是无法治愈的.
现实世界数据 (RWD) 提供了对标准护理结果和潜在治愈能力的见解.
评估未被选择的MBC患者的长期存活率至关重要.

研究的目的:

评估使用RWD.的MBC患者的长期存活率 (OS ≥10年) 和潜在治愈能力.
确定与MBC中长期存活相关的因素.
将现实世界治疗结果 (TTNT,OS) 与已发表的临床试验数据进行比较.

主要方法:

未来收集和分析患者,瘤和治疗特征.
单变量和多变量分析以确定10年以上的OS预测因素.
长期幸存者 (LTS) 和长期响应者 (LTR) 的定义基于OS值.
将RWD结局与历史临床试验数据进行比较.

主要成果:

分析了1999年至2021年间诊断的920名MBC患者.
与10年以上的生存期相关的因素包括新发MBC,单一转移部位,HER2阳性状态和临床试验参与 (p < 0.001).
16%的患者实现了LTS或LTR,其中8.7%的患者可能治愈. 第一线化疗和内分泌疗法显示出与已发表的数据相比的或更好的结果.

结论:

在现实世界中,有效的临床试验结果是可以实现的.
对于MBC患者来说,长期生存 (OS ≥10年),持久的反应和潜在的治愈是可能的.
RWD为MBC管理提供了宝贵的长期结果数据和乐观情绪.

关键词:

基于证据的治疗疗效.长期跟进长期跟进一种潜在的治疗方法.未来数据收集的前景数据收集现实世界的数据数据.

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