"治疗儿童脑瘤后内分泌疾病:长期结果和危险因素"
Gerdi Tuli1,2, Jessica Munarin1,2, Paola Ragazzi3
1Department of Pediatric Endocrinology, Regina Margherita Children's Hospital, AOU Città della Salute e della Scienza, Turin, Italy.
The Journal of clinical endocrinology and metabolism
|February 16, 2026
概括
儿童大脑瘤幸存者经常发展内分泌系统疾病,特别是中央甲状腺功能低下症和生长激素缺乏症. 早期诊断和终身监测对于管理这些长期影响至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 内分泌学 在内分泌学.
- 神经瘤学神经瘤学
背景情况:
- 儿童大脑瘤的幸存者面临着显著的下丘脑-垂体功能障碍的风险.
- 在不同瘤类型和治疗方法之间存在有限的比较数据.
- 了解这些风险对于长期患者护理至关重要.
研究的目的:
- 评估儿童大脑癌症幸存者的下丘脑下垂体疾病的患病率,风险因素和发病时间.
- 根据瘤组织型和治疗暴露来分析这些结果.
主要方法:
- 在18岁之前诊断的388名患者的回顾性队列分析.
- 从医疗记录中提取人口,临床和治疗数据.
- 根据国际标准进行标准化内分泌评估,并根据国际标准对疾病进行分类.
主要成果:
- 75.8%的幸存者患上了内分泌系统疾病,其中瘤和生殖细胞瘤的发病率最高.
- 最常见的缺陷包括中央甲状腺功能低下症,中央早熟青春期和生长激素缺陷.
- 与手术相关的早期发病障碍;晚期发病的放射治疗/化疗. 年轻的年龄和瘤位置预测了发病率.
结论:
- 综合分析内分泌结果按瘤类型,治疗和发病时间表.
- 强调需要对儿童脑瘤幸存者进行个性化的终身内分泌监测.
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