从抽到放松:肥胖失调了肌肉收缩功能
L Cesanelli1, H Degens1,2, P Minderis1
1Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, Lithuania.
Physiological reports
|February 16, 2026
概括
肥胖会损害神经肌肉功能,减少肌肉力量和减缓肌肉收缩,无论是在小鼠和人类. 这会影响相对于体重的强度和整体体能.
科学领域:
- 神经肌肉生理学 神经肌肉生理学
- 肥胖问题研究研究
- 翻译科学 翻译科学
背景情况:
- 肥胖越来越被认为是一种影响神经肌肉功能的疾病.
- 相对于体重,肌肉力量受损是肥胖的一个已知的后果.
- 肥胖对肌肉收缩动态的影响需要进一步调查.
研究的目的:
- 为了研究肥胖对肌肉力量产生的影响.
- 为了确定肥胖是否会改变肌肉收缩和放松动态.
- 评估肥胖对神经肌肉功能的转化影响,从小鼠到人类.
主要方法:
- 在实验室中评估了延伸指长 (EDL) 和单 (SOL) 肌肉在控制 (CN) 和饮食诱导的肥胖 (OB) 雄性小鼠的收缩性质.
- 在正常体重 (CN) 和I类肥胖 (OB) 久坐的男性中评估足部曲器的性能,使用最大自愿的同位数收缩和动态小腿抬起测试.
- 在两种物种中,肥胖和对照组之间的比较特异力,力量发展率和放松动力学.
主要成果:
- 肥胖小鼠在EDL和SOL肌肉中表现出较低的特异力和较慢的力量发展和放松率,与对照组相比.
- 肥胖男性表现出扭矩发展速度较低,足部 flexors的延长放松动力学.
- 肥胖男性的身体质量与最大自愿异度扭矩比较高,这有助于缓慢的小牛抬起阶段.
结论:
- 肥胖会对肌肉力量产生能力产生负面影响.
- 肥胖会导致肌肉收缩动力学变慢,影响力产生和放松.
- 这些发现突显了不同物种中与肥胖相关的显著神经肌肉损伤.
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