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Updated: Feb 17, 2026

Harvesting and Cryo-cooling Crystals of Membrane Proteins Grown in Lipidic Mesophases for Structure Determination by Macromolecular Crystallography
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Published on: September 2, 2012

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在粘附 GPCR 中的类固醇识别:结构和药理学的视角

Bethany Fleming1, Abdul-Akim Guseinov1, Irina G Tikhonova2

  • 1Centre for Translational Pharmacology, School of Molecular Biosciences, University of Glasgow, Glasgow, UK, Scotland.

Pharmacology research & perspectives
|February 16, 2026
PubMed
概括

类固醇可能与粘附性G蛋白结合受体 (GPCRs) 结合,这是一个有前途的药物标类. 结构研究揭示了ADGRD1中的类固醇结合口袋,这表明GPCRs之间有一个共享的识别机制.

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