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Updated: Feb 17, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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Published on: July 25, 2019

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人类DNA聚合酶 η是通过相互排斥的单一-ubiquitination和单一-NEDDylation来调节的

Natália C Moreno1,2, Emilie J Korchak3, Marcela T Latancia1

  • 1Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3371, United States.

Nucleic acids research
|February 16, 2026
PubMed
概括

DNA聚合酶eta (Pol η) 是由类似于乌比奎丁的蛋白NEDD8.8调节的. 这种单NEDDylation阻止Pol η在紫外线照射的细胞中形成焦点,影响转化DNA合成.

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