美国主要表单变化触发了,但并没有维持,生物类似的阿达利穆马布处方增加
Eric T Roberts1, Gabriela Schmajuk1,2, Mackenzie Clark1
1University of California San Francisco, San Francisco, CA.
Arthritis care & research
|February 16, 2026
概括
一个主要的配方改变最初促进了生物类似的阿达利穆马布的处方,但效果没有持续. 诸如nocebo效应和行政障碍等障碍限制了生物类似药的采用和成本节省.
科学领域:
- 类风湿病学 类风湿病学
- 药物经济学 药物经济学
- 医疗保健服务研究 医疗服务研究
背景情况:
- CVS Caremark在2024年更新了国家商业配方,优先选择阿达利穆马布-阿达兹而不是原始生物.
- 这种配方变化旨在影响在临床实践中采用生物类似的阿达利穆马布.
研究的目的:
- 评估CVS Caremark表单更改对美国社区风湿病学实践中生物类似的阿达利穆马布 (阿达利穆马布-阿达兹和其他生物类似药物) 处方模式的影响.
- 分析按付款人分层和新用户分层的处方趋势.
主要方法:
- 利用来自RISE注册的电子健康记录数据的中断时间序列分析.
- 从2023年1月到2024年9月,检查了阿达利穆马布-阿达兹和其他阿达利穆马布生物类似药的每月处方比例.
- 通过商业保险和医疗保险进行了分层分析,并专注于新患者用户.
主要成果:
- 在商业保险患者中,阿达利穆马布-阿达兹的处方从近0%上升到表格变更后的25%以上,随后下降12.3%. 其他生物类似药的处方出现了缓慢,线性增长.
- 新用户的情况也呈现出类似的趋势:阿达利穆马布-阿达兹的使用率上升至24%,然后下降近14%. 其他生物类似药的处方每月增加0.6%.
- 接受医疗保险的患者在阿达利姆巴-阿达斯和其他生物类似药物处方中经历了较小,相似的时间增加,但随后没有显著下降.
结论:
- 尽管在配方更改后,生物类似的阿达利穆马布处方最初急剧增加,但这些收益并没有持续.
- 持续存在的障碍,包括nocebo效应和与更换药物相关的行政负担,阻碍了生物类似药的更广泛采用.
- 这些挑战限制了美国医疗保健市场对阿达利穆马布治疗的潜在成本节约.
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