基于运动的计划对中性粒细胞-淋巴细胞比率和年轻发病糖尿病患者的血糖控制的影响:一项随机对照试验
Anupama Harihar1, Sahana Shetty2, Shyamasunder Bhat N3
1Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India.
在患有2型糖尿病 (T2DM) 的年轻成年人中,一项为期12周的运动计划显著降低了炎症并改善了血糖控制. 这种干预,结合有氧和抵抗训练,为管理T2DM并发症提供了有益的方法.
科学领域:
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 年轻发病的2型糖尿病 (T2DM) 呈现出越来越多的健康问题,患病率和相关发病率的增加.
- 持续的低度系统性炎症和不充分的血糖控制有助于年轻T2DM患者早期出现并发症.
研究的目的:
- 评估基于运动的干预措施对中性粒细胞-淋巴细胞比率 (NLR) 和血糖标记 (禁食血糖 - FBG,糖化血红蛋白 - HbA1c) 的有效性.
- 评估在被诊断为年轻发病T2DM的个体中这些影响.
主要方法:
- 一项随机对照试验,涉及84名患有T2DM的参与者 (18-40岁),分为干预组或对照组.
- 干预组接受了为期12周的综合有氧和抵抗训练 (中度至强度) 计划,并接受了标准糖尿病护理.
- 在基线,12周和24周测量了NLR,HbA1c和FBG. 用线性混合效应模型分析数据.
主要成果:
- 与对照组相比,干预组在24周内显示了NLR在统计学上显著的减少 (p < 0.001).
- 在干预组中,在12周和24周的HbA1c (p < 0.001) 和12周和24周的FBG (p < 0.034) 中观察到显著改善.
结论:
- 一个12周的运动计划,包括有氧和抵抗训练,有效地减少系统性炎症 (NLR) 和增强血糖控制 (HbA1c,FBG) 在年轻发病的T2DM.
- 这种炼方案与标准糖尿病护理相比,对于这一群体来说,显示出有益的影响.
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