作为小儿耐药性的辅助疗法的益生菌补充:双盲安慰剂受控试验
Amira R Rashdan1, Sahar M El-Haggar1, Ahmed Mustafa Kishk2
1Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Pharmacotherapy
|February 16, 2026
概括
补充Lactobacillus acidophilus显著降低了抗药性的儿童的发作频率和改善了他们的生活质量. 这种益生菌干预也降低了关键的炎症标志物,这表明它在通过肠-大脑轴调节来控制的作用.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 临床医学 临床医学
背景情况:
- 耐药性 (DRE) 越来越多地与神经炎症和肠道失调有关.
- 这些因素损害了血脑屏障的完整性,增加了发作的易感性.
- 针对微生物群的干预措施显示了的治疗潜力.
研究的目的:
- 评估益生菌作为DRE儿童辅助治疗的有效性.
- 评估益生菌对药物敏感性和临床结果的影响.
- 研究益生菌对炎症标志物的作用.
主要方法:
- 一个为期6个月的随机,双盲,安慰剂对照试验,涉及60名患有DRE的儿科患者.
- 参与者接受了标准的抗药物,再加上Lactobacillus acidophilus或安慰剂.
- 主要结局包括发作频率和生活质量 (QOLCE-55);次要结局包括血清炎症标志物 (HMGB1,IL-1β,Hcy,NLRP3).
主要成果:
- 与安慰剂相比,益生菌组的发作频率显著降低 (p=0.04) 并改善了QOLCE-55得分 (p<0.0001).
- 在益生菌组中观察到血清HMGB1,NLRP3,Hcy和IL-1β水平的显著下降.
- 这些发现表明,Lactobacillus acidophilus对DRE中的临床和生化标志物都有积极的影响.
结论:
- 补充Lactobacillus acidophilus可能会在患有DRE的儿童中增强常规抗药物的疗效.
- 益生菌使用似乎可以减少全身炎症并改善生活质量.
- 需要进一步的研究来验证这些有希望的研究结果对DRE管理.
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