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一个Ppb级的MIR-PAS对CO2的同位素分析,以在线的基于呼吸的H. pylori传感

Yubing Yang¹, Xukun Yin², Xiu Yang²

¹Shandong Provincial Engineering Research Center of Intelligent Sensing and Measurement and Control Technology, College of Control Science and Engineering, China University of Petroleum (East China), Qingdao 266580, China.

|February 16, 2026

概括

一个新的中红外光声谱系统可以实时检测二氧化碳同位素,以快速诊断Helicobacter pylori. 这项技术为当前的呼吸测试提供了一个有希望的非侵入性的替代方案.

科学领域:

分析化学分析化学
频谱学是一种光谱学.
生物医学工程生物医学工程

背景情况:

杆菌感染与胃疾病有关,需要有效的诊断工具.
由于线下呼吸样本处理,现有的13C-尿素呼吸测试 (13C-UBT) 缺乏实时分析.
非侵入性,快速诊断对于及时检测和管理H. pylori至关重要.

研究的目的:

开发一个中红外光声谱 (MIR-PAS) 系统,用于实时检测二氧化碳同位素.
评估系统的性能,以评估13C-UBT响应.
为了证明MIR-PAS在护理地点H.pylori诊断中的潜力.

主要方法:

设计了一个双通道差异共振光声细胞 (DPAC),样本体积为10.3毫升.
一个4.35μm量子级联激光器针对特定的12CO2和13CO2吸收线进行同位素区分.
描述了系统的响应,检测极限和CO2同位素的精度.

主要成果:

该MIR-PAS传感器实现了优异的线性 (R2>0.994) 和低的检测极限 (8.98ppb为12CO2,2.81ppb为13CO2).
δ13C测量显示高精度 (0.066‰在76秒的平均时间).
呼吸采样测试证实了独特的时间CO2同位素释放模式.

结论:

开发的MIR-PAS系统是一个紧,灵敏和强大的平台,用于同位素二氧化碳分析.
该系统展示了实时,护理点H. pylori诊断的巨大潜力.
这项技术可以克服当前离线呼吸测试分析的局限性.

关键词:

二氧化碳二氧化碳二氧化碳在Helicobacter Pylori的研究中,这是一种同位素同位素.时间时间时间时间时间量子级联激光器是一种量子级联激光器.

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