评估患有唐氏综合征和痴呆症的个体的认知功能:系统性审查
Ana Clara Lira do Nascimento1, Egeval Pereira da Paz1, Graziela Rosa Lopes Bastos Freire1
1Universidade de Pernambuco, School of Medicine, Group of Geriatrics, Recife PE, Brazil.
Dementia & neuropsychologia
|February 16, 2026
概括
患有唐氏综合征 (DS) 的个人经历痴呆症,通常是阿尔茨海默氏症 (AD). 早期诊断具有挑战性,但行为变化可能标志着DS中痴呆症的发病.
科学领域:
- 神经学 神经学
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 患有唐氏综合征 (DS) 的人患痴呆症的风险显著增加,包括阿尔茨海默病 (AD).
- 在DS中存在的先前认知差异的存在使得痴呆症的早期和准确诊断变得复杂.
- 对于在DS患者群体中针对痴呆症量身定制的特定诊断标准的需求至关重要.
研究的目的:
- 在患有唐氏综合征的个体中划分痴呆症的认知和行为表现.
- 批判性地评估现有的认知评估工具的实用性和适用性,以诊断DS患者的痴呆症.
主要方法:
- 在2014-2024年期间,在主要数据库 (PubMed,Scopus,Web of Science,BVS) 中按照PRISMA指南进行了系统的文献搜索.
- 如果研究发表在英语,葡萄牙语或西班牙语中,则将其纳入研究,并使用STROBE标准评估其质量.
- 在选了254个记录后,共包括了28项研究.
主要成果:
- 早期痴呆症的特征是执行功能,记忆力,语言和注意力下降.
- 经常观察到显著的行为变化,如兴奋,幻觉和冷漠.
- 这些行为症状似乎在阿尔茨海默氏症-唐氏综合征 (AD-DS) 和先发性痴呆阶段都很突出,这表明它们可能是早期指标.
结论:
- 唐氏综合征患者的痴呆症呈现出明显的认知和行为衰退模式.
- 行为症状正在成为DS人口中痴呆症的关键早期诊断标志物.
- 进一步的研究和特定的诊断工具是有必要的,以改善早期发现和管理的痴呆症在DS.
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