通过协作领域适应改善晚年抑郁症分析:从异质结构性MRI学习
Yuzhen Gao1, Mengqi Wu1, Li Wang1
1Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
概括
使用脑MRI准确识别晚年抑郁症 (LLD) 通过新的协作域适应 (CDA) 框架得到了改进. 这种方法通过利用大型数据集来提高模型可靠性和概括性,以更好地检测LLD.
科学领域:
- 神经成像是一种神经成像.
- 人工智能的人工智能
- 老年精神病学是一门精神病学专业.
背景情况:
- 通过脑MRI准确识别晚年抑郁症 (LLD) 对临床监测至关重要.
- 现有LLD研究中的有限数据损害了模型可靠性.
- 跨研究的MRI数据采集的异质性阻碍了概括性.
研究的目的:
- 提出一个协作域适应 (CDA) 框架,用于使用T1加权的MRI检测LLD.
- 利用来自大型辅助数据集的知识来改善在小型目标数据集中的LLD检测.
- 为了提高LLD检测模型在不同MRI采集设置中的通用性.
主要方法:
- 开发了一个CDA框架,整合了全球特征的视觉转换器 (ViT) 和局部特征的卷积神经网络 (CNN).
- 预先训练有素的ViT和CNN编码器对9544张来自公共群体的MRI进行了预先训练.
- 员工监督培训,特征对齐微调,以及对未标记的目标MRI与增强样本的协作培训.
主要成果:
- 与LLD检测中最先进的方法相比,CDA框架显示出更高的性能.
- 从238名受试者获得T1加权的MRI的更高分类准确度.
- 展示了改进的跨领域概括能力.
结论:
- 拟议的CDA框架有效地解决了LLDMRI研究中的数据限制和异质性.
- CDA为可靠和可通用的LLD检测提供了一个强大的解决方案.
- 这种方法有望促进晚年抑郁症的临床监测.
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