氧化应激生物标志物与冠心病之间的关系:从发病到治疗方面
Aneeza Waris Hussain Rathore1, Hira Naveed1, Atif Nadeem1
1Department of Cardiology, Army Cardiac Hospital/CMH Lahore Medical College, Lahore 54000, Punjab, Pakistan.
World journal of cardiology
|February 16, 2026
概括
氧化应激和炎症是冠心病 (CHD) 发展和进展的关键驱动因素. 本综述强调了关键的氧化应激生物标志物和在心脏病患者中管理它们的策略.
科学领域:
- 心血管医学 心血管医学
- 生物化学 生物化学
- 病理生理学 病理生理学
背景情况:
- 冠心病 (CHD) 病理生理学涉及氧化应激和炎症,有助于动脉样硬化.
- 降低抗氧化防御和高氧化应激加快冠状动脉疾病 (CAD) 的发展和进展.
- 许多氧化应激生物标志物与CAD有关.
研究的目的:
- 总结各种氧化应激生物标志物在心脏病发病的作用.
- 讨论氧化应激对冠状动脉疾病的影响.
- 探索治疗策略,以管理心脏病中氧化应激.
主要方法:
- 文献综述侧重于心脏病中氧化应激生物标志物.
- 分析特定生物标记物的作用,包括偏氧酶,甲酸,甲酸过氧酶,先进的糖化最终产品,8-氧化氨酸,甲酸,超氧化解酶,甲酸,异素,甲酸和活性氧化代谢物.
- 综合有关氧化应激和心血管疾病发病之间的联系的信息.
主要成果:
- 帕洛克索纳斯,尼铁素,谷氨酸过氧化酶,先进的糖化最终产品,8-基氧化氨酸,烯氧化酶,超氧化失调酶,马隆迪甲基,异醇,酶和活性氧化代谢物在心血管疾病的发病过程中具有重要意义.
- 氧化应激生物标志物为CHD的机制提供了洞察力.
- 这些生物标志物与动脉样硬化的发展和进展有关.
结论:
- 控制氧化应激指标对于控制心血管疾病至关重要.
- 改变生活方式和针对活性氧物种的药理干预是关键策略.
- 了解氧化应激生物标志物有助于心血管疾病的管理和治疗.
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