双相溶解微针与循环二烯含有复合物,用于增强难溶药物的递送
Runze Wang1, Jiaqi Cao1, Jing Zou1
1School of Pharmaceutical Sciences, Zhengzhou University Zhengzhou Henan China guo5566@126.com.
RSC advances
|February 16, 2026
概括
这项研究引入了一种新型的溶解微针 (DMN) 系统,使用基基基基基基 (HP-β-CD) 来增强通过皮肤递送flurbiprofen (FB) 的药物. 与商业贴片相比,开发的DMN显著提高了药物负载和生物可用性.
科学领域:
- 生物材料科学 生物材料科学
- 药品制造 药品制造 药品制造
- 药物输送系统 药物输送系统
背景情况:
- 溶解微针 (DMN) 显示出通过皮肤递送药物的前景,但药物载荷能力受到限制.
- 难以溶解的药物对有效的通过皮肤给药构成重大挑战.
研究的目的:
- 开发一个高容量的DMN平台,用于通过皮肤递送flurbiprofen (FB),一种溶性较差的药物.
- 通过HP-β-CD纳入和双相微针设计来增强药物负载并改善药理学概况.
主要方法:
- 两相DMN的制造,其中包含基-β-环氧化 (HP-β-CD) 用于flurbiprofen (FB) 的装载.
- 描述微针形态,机械强度和药物释放动力学.
- 使用老鼠皮肤的体外透研究和在老鼠体内药理动力学研究,将DMN与商用凝贴片进行比较.
主要成果:
- 微针显示出足够的机械强度 (0.58 ± 0.10 N 断裂力) 穿透皮肤.
- 实现了高药物负载能力 (每片100针的补丁为2.67±0.11毫克).
- 在体内研究显示,与商用凝贴片相比,生物可用性增加了2.6倍,Tmax更快 (2小时 vs 8小时).
结论:
- 这种FB/HP-β-CD纳入的双相DMN系统有效地增强了难溶性药物的通过皮肤递送.
- 这个平台提供了一个有希望的策略,以克服DMN临床翻译和商业化方面的局限性.
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