疲劳的病理生理机制和多学科管理策略 (综述)
Hong Zhou1, Wenwen Yu1, Jiaming Lei1
1Key Laboratory of Environmental Related Diseases and One Health, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China.
Experimental and therapeutic medicine
|February 16, 2026
概括
疲劳涉及能量代谢,神经内分泌和免疫系统的复杂相互作用. 了解这些机制是有效的临床诊断和管理策略的关键.
科学领域:
- 分子生物学分子生物学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 代谢学 代谢学 代谢学
背景情况:
- 疲劳是一种普遍的临床症状,影响患者的生活质量和社会功能.
- 了解疲劳机制是由omics技术和人工智能增强的.
- 疲劳涉及能量代谢,神经内分泌和免疫系统的多层次调节.
研究的目的:
- 审查疲劳的概念框架,生理机制,临床表现和管理策略.
- 为临床诊断和治疗实践提供参考.
- 突出奥米克和AI在疲劳研究中的作用.
主要方法:
- 审查关于疲劳机制和管理的现有文献.
- 对奥米克数据和分子生物学发现的分析.
- 检查临床表现和治疗模式.
主要成果:
- 异常的能量代谢,氧化应激和线粒体功能障碍是疲劳致病的核心原因.
- 神经内分泌-免疫网络障碍和微生物群-肠-大脑轴功能障碍是关键的整合机制.
- 疲劳是各种疾病的症状,如慢性疲劳综合征,内分泌,神经和自身免疫系统疾病.
结论:
- 个性化,多学科的管理模式和远程医疗改善了疲劳护理.
- 未来的研究应该集中在分子机制,新型干预,评估模型和优化管理上.
- 分子机制的翻译应用和基于证据的支持对于临床实践至关重要.
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