在一个国家精神病医院的抗精神病药物处方模式,主要是法医的入院
Nina Vadiei1,2,3
1College of Pharmacy, The University of Texas at Austin, Austin, TX, United States.
Frontiers in psychiatry
|February 16, 2026
概括
高剂量的抗精神病药物使用和抗精神病药物多药在美国州立精神病医院中很常见. 需要进一步的研究,以了解处方变化,并实施严重精神疾病 (SMI) 治疗的管理计划.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 没有发表的研究评估了美国州立医院的抗精神病药物处方模式.
- 国家医院治疗严重精神疾病 (SMI) 患者,通常需要抗精神病药物.
- 抗精神病药物具有剂量依赖的副作用,需要谨慎处方.
研究的目的:
- 描述美国一家州立精神病医院的抗精神病药物处方模式.
- 确定高剂量抗精神病药物使用和抗精神病药物多药 (APP) 的流行情况.
- 为公立医院环境中抗精神病药物使用提供最佳实践信息.
主要方法:
- 在一个单一的州精神病医院的横截图表审查.
- 收集关于人口统计,入院类型,诊断和抗精神病药物选择/剂量的数据.
- 高剂量使用定义为超过典型的最大每日剂量.
主要成果:
- 在212例患者中,近三分之二的患者接受了与典型的最大剂量或以上的抗精神病药物.
- 抗精神病多种药物 (APP) 处方率为35.8% (两种抗精神病药物) 和6.1% (三种抗精神病药物).
- 常见的处方:奥兰扎宾 (35.8%),克洛扎宾 (24.1%),帕利佩里 (23.1%);20.3%接受第一代抗精神病药物;32.5%接受长效注射剂 (LAIA).
结论:
- 高剂量的抗精神病药物使用和APP在这个美国州立精神病医院中很普遍.
- 需要进行多中心研究来评估各州医院处方模式的差异.
- 建议制定抗精神病药物管理计划,以优化使用和监测结果.
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